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EXPLANATION
✔Correct answer:
Bone marrow suppression. Chloramphenicol is an antibiotic that, while effective for treating serious infections, has a high potential for toxic effects, the most serious of which is bone marrow suppression. This adverse reaction can manifest in two forms: reversible bone marrow suppression (which is dose-dependent and resolves upon discontinuation of the drug) and aplastic anemia, a rare but often fatal form of bone marrow failure that is not dose-dependent and may occur weeks or even months after stopping the medication.
Bone marrow suppression can lead to decreased production of blood cells, resulting in pancytopenia (reduction in red blood cells, white blood cells, and platelets). This puts the patient at risk for anemia, infections, and bleeding. Due to the risk of this life-threatening adverse effect, chloramphenicol use is generally restricted to severe infections for which other, safer antibiotics are ineffective or contraindicated.
Think of the bone marrow as a factory that produces essential supplies (blood cells) for the body. Chloramphenicol, like a toxic chemical in the factory, can damage the production lines, leading to a severe shortage of supplies (blood cells), which affects the entire system.
Nurses should closely monitor patients receiving chloramphenicol, especially for signs of bone marrow suppression. Regular blood work is essential to detect early signs of hematologic toxicity, allowing for prompt intervention.
- Monitor complete blood count (CBC) regularly, focusing on hemoglobin, white blood cell, and platelet levels.
- Educate the patient to report signs of infection (e.g., fever, sore throat), unusual bleeding or bruising, and fatigue, which may indicate bone marrow suppression.
- Discontinue the drug and alert the healthcare provider if any signs of bone marrow toxicity are observed.
- Minimize the duration of chloramphenicol therapy to reduce the risk of toxicity.
- Advise the patient about the importance of follow-up blood tests even after stopping the drug, as delayed reactions can occur.
✘Incorrect answer options:
Lethal arrhythmias — While arrhythmias can be adverse reactions to some medications, they are not associated with chloramphenicol. Chloramphenicol’s toxic profile primarily affects the bone marrow.
Malignant hypertension — Malignant hypertension, an extreme and potentially life-threatening increase in blood pressure, is not linked to chloramphenicol use. This adverse effect is more common with certain other medications, like those affecting the autonomic nervous system.
Status epilepticus — Status epilepticus, a continuous seizure state, is not a known adverse reaction to chloramphenicol. Neurological side effects are not common with this antibiotic, compared to its hematologic toxicity.
References
- Lehne, R. A., & Rosenthal, L. (2019). Pharmacology for Nursing Care. Elsevier.
- Burchum, J. R., & Rosenthal, L. D. (2020). Lehne’s Pharmacology for Nursing Care. Elsevier.