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EXPLANATION
✔Correct answer:
Tinnitus. Acute aspirin toxicity, also known as salicylism or salicylate poisoning, occurs when there is an excessive accumulation of salicylates in the body. One hallmark symptom of acute aspirin toxicity is tinnitus, which refers to a ringing or buzzing sensation in the ears. This occurs due to the ototoxic effects of high salicylate levels, which interfere with the function of the cochlea in the inner ear. Salicylates disrupt normal cellular metabolism and electrolyte balance, leading to symptoms such as tinnitus, hearing loss, hyperventilation, and metabolic acidosis. Monitoring for tinnitus is critical because it often precedes more severe complications, such as respiratory alkalosis and central nervous system disturbances.
Aspirin (acetylsalicylic acid) is metabolized in the liver and excreted by the kidneys. At therapeutic doses, aspirin inhibits cyclooxygenase enzymes, reducing inflammation, pain, and fever. However, at toxic levels, aspirin uncouples oxidative phosphorylation in mitochondria, leading to increased oxygen consumption, lactate production, and metabolic acidosis. The central nervous system becomes overstimulated, resulting in symptoms like tinnitus, confusion, and seizures.
Think of aspirin as a car engine running smoothly at low speeds (therapeutic dose). If you rev the engine too high (toxic dose), it starts making strange noises (tinnitus) and may eventually overheat (severe toxicity).
Nurses should be vigilant in monitoring patients on aspirin therapy, especially those receiving high doses for conditions like rheumatoid arthritis. Key interventions include:
- Assessing for early signs of aspirin toxicity, such as tinnitus, headache, nausea, and dizziness.
- Monitoring vital signs, including respiratory rate and depth, as hyperventilation is common in salicylate toxicity.
- Educating the patient about the importance of adhering to prescribed dosages and recognizing symptoms of toxicity.
- Collaborating with the healthcare provider to adjust dosages or discontinue aspirin if toxicity is suspected.
- In cases of confirmed toxicity, preparing for interventions such as activated charcoal administration, intravenous fluids, and bicarbonate therapy to correct acid-base imbalances.
✘Incorrect answer options:
Anorexia. While anorexia (loss of appetite) can occur with chronic aspirin use or mild toxicity, it is not a specific indicator of acute aspirin toxicity. Anorexia is a nonspecific symptom that could result from various causes, including gastrointestinal irritation or other systemic illnesses.
Diarrhea. Diarrhea is not a characteristic symptom of acute aspirin toxicity. Gastrointestinal upset, such as nausea and vomiting, is more commonly associated with aspirin use, but diarrhea is not a hallmark sign of toxicity.
Pruritus. Pruritus (itching) is unrelated to aspirin toxicity. It is more commonly associated with allergic reactions, dermatological conditions, or cholestatic liver disease rather than salicylate overdose.
References
- Brunner & Suddarth's Textbook of Medical-Surgical Nursing (14th ed.). (2018). Wolters Kluwer.
- Goldfrank, L. R., & Nelson, L. S. (2019). Goldfrank’s Toxicologic Emergencies (11th ed.). McGraw-Hill Education.