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EXPLANATION
✔Correct answer:
Non-benzodiazepine sedatives (e.g., Z-drugs). Non-benzodiazepine sedatives, commonly known as Z-drugs (like zolpidem, eszopiclone, and zaleplon), are considered a safer option for promoting sleep in adult patients. These drugs are preferred over benzodiazepines and barbiturates because they have a lower risk of dependence, fewer side effects, and a shorter half-life, which reduces the likelihood of daytime drowsiness or hangover effects. Z-drugs are specifically designed to target receptors that help induce sleep without significantly affecting other functions of the central nervous system.
From a nursing perspective, these medications are often used for short-term treatment of insomnia. They work on the gamma-aminobutyric acid (GABA) receptors similarly to benzodiazepines but are more selective in targeting the subtypes of GABA receptors involved in sleep. As a result, Z-drugs have a more favorable safety profile, particularly for elderly patients, as they are less likely to cause confusion, falls, or cognitive impairment.
Think of non-benzodiazepine sedatives (Z-drugs) like a specialized key that only fits into a specific lock—one that opens the door to sleep but doesn’t unlock other functions in the brain. This helps minimize side effects and makes them safer for promoting sleep.
When administering non-benzodiazepine sedatives, it's important for nurses to assess the patient's individual situation, educate them on proper usage, and monitor for any adverse effects. While these medications are generally safer than other sedative options, nurses should still remain vigilant for potential issues such as sedation, confusion, or misuse, especially in vulnerable populations like the elderly.
- Assess for any contraindications like existing sleep apnea, as sedatives can worsen respiratory conditions.
- Educate patients on using these medications only as prescribed and avoid long-term use to reduce dependence.
- Monitor for any signs of next-day sedation or confusion, especially in older adults.
- Encourage non-pharmacological sleep aids such as sleep hygiene practices before initiating drug therapy.
✘Incorrect answer options:
Barbiturates: Barbiturates are no longer recommended for treating insomnia due to their high risk of dependence, overdose, and severe side effects, such as respiratory depression. They have a much higher potential for abuse and can easily lead to life-threatening toxicity, even at therapeutic doses. This class of drugs is now mostly reserved for specific uses, such as seizure control or anesthesia induction, and is rarely used for insomnia.
Benzodiazepines: While benzodiazepines (e.g., diazepam, lorazepam) can help with sleep by enhancing the effects of GABA in the brain, they are not considered the safest option due to their potential for dependence, tolerance, and cognitive side effects, especially in older adults. They also have a higher risk of causing residual drowsiness or confusion the next day, which can increase the risk of falls or accidents. In addition, benzodiazepines can disrupt the natural sleep architecture, reducing deep, restorative sleep.
Antihistamines: Over-the-counter antihistamines (e.g., diphenhydramine) are sometimes used as sleep aids due to their sedative properties, but they are not the safest option. While they may induce drowsiness, they often have undesirable side effects such as dry mouth, urinary retention, and blurred vision, particularly in older adults. They can also cause daytime drowsiness and impair cognitive function. Furthermore, the body can quickly build a tolerance to their sedative effects, making them less effective over time.
References
- Ignatavicius, D. D., Workman, M. L., & Rebar, C. R. (2021). Medical-Surgical Nursing: Concepts for Interprofessional Collaborative Care (10th ed.). Elsevier.
- Urden, L. D., Stacy, K. M., & Lough, M. E. (2018). Critical Care Nursing: Diagnosis and Management (8th ed.). Elsevier.