Text Mode – Text version of the exam 1. If we consider the given medical parameters – increased pH, typical bicarbonate levels (HCO3), ordinary base excess (BE), and decreased partial pressure of carbon dioxide (pCO2), to which of these physiological states does this constellation of factors most likely correspond? A. Respiratory alkalosis 2. If we look at the commonly accepted normal range for bicarbonate (HCO3) in the human body, how is this typically expressed in milliequivalents per liter (mEq/L)? A. From 15 to 30 mEq/L. 3. Given the following criteria, which most accurately represents a negative reaction to the Tuberculin Skin Test (TST) for tuberculosis (TB)? A. Induration measuring between 0 to 4 millimeters after 48 hours. 4. Given these physiological observations: – Elevated pH levels Which condition is most likely to be associated with this combination of indicators? A. Metabolic acidosis 5. Among the following cellular entities, which is responsible for the production and secretion of surfactant? A. Ciliated columnar epithelial cell. 6. Looking at the following respiratory terminologies, which term corresponds with the observation of blockage in the trachea or larynx? A. Wheezes 7. When referring to standard measurements of partial pressure of carbon dioxide (pCO2) in the human body, what is the range typically expressed in millimeters of mercury (mmHg)? A. Between 35 to 45 mmHg. 8. The vital control center that manages our breathing patterns is situated within which two sections of the brain? A. Medulla oblongata and Hypothalamus. 9. Out of the following varieties, which form of lung cancer is most frequently diagnosed? A. Adenocarcinoma 10. Reflecting on the subsequent biological indicators: – Reduced pH levels Which physiological state could be connected with this specific set of attributes? A. Respiratory acidosis 11. Among the following conditions, which one is not typically associated with Chronic Obstructive Pulmonary Disease (COPD)? A. Bronchitis 12. Can you identify the term from the list of pulmonary concepts that corresponds to the phenomenon of bronchial wall spasms? A. Stridor 13. Out of the following medications, which one is recognized as an expectorant, aiding in the expulsion of mucus from the lungs? A. Benadryl 14. From the following list of medications, which one is recognized as a bronchodilator, designed to widen the bronchi and bronchioles to facilitate breathing? A. Acetaminophen 15. Among the given medications, which one is typically used to combat infections caused by Pneumocystis carinii, a type of fungus? A. Lorazepam 16. Out of the provided list of drugs, which one belongs to the class of compounds known as xanthines? A. Epinephrine Hydrochloride 17. Among the following health issues, which one is not typically a result of Chronic Obstructive Pulmonary Disease (COPD)? A. Right-sided heart failure 18. Among the medications listed, which one is classified as a mucolytic, a drug that breaks down mucus to help clear the airways? A. Acetylcysteine 19. Considering the following respiratory terms, which one aligns with the definition: The maximum amount of air that can be forcefully expelled after taking the deepest possible inhalation? A. Inspiratory Reserve Volume 20. Among the following respiratory terms, which one fits the description: The quantity of air that can be drawn in after the expiration of a normal tidal volume? A. Inspiratory Reserve Volume 1. Correct answer: A. Respiratory alkalosis. In the given scenario, the patient presents with an increased pH and decreased partial pressure of carbon dioxide (pCO2), while bicarbonate levels (HCO3) and base excess (BE) are within normal ranges. This pattern aligns with the diagnosis of respiratory alkalosis. Respiratory alkalosis is a condition that occurs when there is a primary decrease in the partial pressure of carbon dioxide (pCO2) due to hyperventilation. The decreased pCO2 level in the blood results in an increase in blood pH (alkalosis), as carbon dioxide combines with water in the body to form carbonic acid, which then dissociates to contribute hydrogen ions (H+) and bicarbonate ions (HCO3-) to body fluids. When CO2 levels fall, this reaction occurs less, resulting in fewer hydrogen ions, which raises the pH of the blood. Incorrect answer options: B. Metabolic acidosis would be characterized by a decreased pH and decreased HCO3 levels, resulting from either an excess of acid (other than CO2) or a deficit of base in the body. C. Respiratory acidosis would involve decreased pH and increased pCO2, which could be due to hypoventilation or a ventilation defect leading to CO2 retention. D. Metabolic alkalosis would present with an increased pH and increased HCO3 levels, which could be due to excessive loss of metabolic acids (such as from prolonged vomiting or the use of certain diuretics) or excessive bicarbonate intake. 2. Correct answer: B. From 22 to 26 mEq/L. The commonly accepted normal range for bicarbonate (HCO3-) concentration in human blood is typically around 22 to 26 milliequivalents per liter (mEq/L). This measure reflects the buffering capacity of the blood, with bicarbonate being the major base in the body that helps to neutralize acids and maintain pH homeostasis. Incorrect answer options: A. From 15 to 30 mEq/L – This range is too broad and includes values that would generally be considered too low or too high for healthy bicarbonate levels. C. From 24 to 29 mEq/L – This range is too narrow on the lower end and a bit too high on the upper end. A bicarbonate level of 24 mEq/L is generally near the lower end of the normal range, not the start of it. D. From 20 to 35 mEq/L – This range includes values that are generally considered too low or too high for normal bicarbonate levels. 3. Correct answer: A. Induration measures between 0 to 4 millimeters after 48 hours. The Tuberculin Skin Test (TST), also known as the Mantoux test, is used to identify individuals who may have been infected with Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB). The test is based on measuring the induration (raised, hard area or swelling) that occurs in response to injection of purified protein derivative (PPD) into the skin. For most individuals, an induration of 0 to 4 millimeters (mm) in size at 48-72 hours post-injection is generally considered a negative reaction, implying that the person likely does not have TB infection. Incorrect answer options: B, C, & D. Indurations measure between 0 to 6 mm, 0 to 5 mm, or 0 to 7 mm after 48 hours. These ranges are incorrect. A reaction size of more than 5 mm could be considered positive in certain high-risk groups, such as people with HIV, recent contacts of TB patients, or individuals with changes on chest radiographs consistent with prior TB disease. 4. Correct answer: C. Metabolic alkalosis. Given the data you’ve provided — elevated pH levels, increased bicarbonate (HCO3) concentration, high base excess (BE), and normal levels of partial pressure of carbon dioxide (pCO2) — the most likely condition associated with these findings is metabolic alkalosis. Metabolic alkalosis occurs when there is an elevation of bicarbonate concentration in the body, often due to the loss of acid from the body or the gain of bicarbonate. This increases the pH of the blood, resulting in alkalosis. The normal pCO2 suggests that the respiratory system is not the primary cause of the change in pH, supporting a metabolic rather than a respiratory origin of the alkalosis. Incorrect answer options: A. Metabolic acidosis would present with decreased pH and decreased bicarbonate levels, which would be due to either an excess of acid (other than CO2) or a deficiency of base in the body. B. Respiratory alkalosis would present with an increased pH and decreased pCO2, which would be due to hyperventilation leading to excessive exhalation of CO2. D. Respiratory acidosis would present with decreased pH and increased pCO2, which would be due to hypoventilation or a ventilation defect leading to CO2 retention. 5. Correct answer: B. Alveolar cell of the second type. Type II alveolar cells, also known as alveolar cells of the second type or pneumocytes, are responsible for the production and secretion of pulmonary surfactant. This substance is critical for reducing surface tension within the alveoli (the tiny air sacs in the lungs), preventing their collapse upon exhalation, and aiding in lung elasticity and gas exchange. Incorrect answer options: A. Ciliated columnar epithelial cells are not primarily involved in the production of surfactant. These cells are found in the upper respiratory tract and their main function is to move mucus and trapped particles upwards and out of the respiratory tract. C. There is no recognized “alveolar cell of the third type”. This may be a misleading or incorrect option in the context of known lung cell types. D. Alveolar cells of the first type (Type I alveolar cells) are not primarily involved in surfactant production. These cells are responsible for the exchange of gases (oxygen and carbon dioxide) between the alveoli and the blood in the surrounding capillaries. They form the majority of the alveolar surface area but do not produce surfactant. 6. Correct answer: C. Stridor. Stridor refers to a high-pitched, wheezing sound caused by disrupted airflow. It is typically caused by blockage or narrowing in the trachea (windpipe) or larynx (voice box) and is often heard during inhalation. It can be a sign of serious respiratory conditions, like foreign body obstruction, laryngeal or tracheal stenosis, and certain types of tumors. Incorrect answer options: A. Wheezes are high-pitched, continuous sounds that are often heard when air is forced through narrowed airways, usually as a result of asthma, chronic obstructive pulmonary disease (COPD), or bronchitis. Wheezing is usually heard during exhalation, not inhalation. B. Vesicular refers to the normal sound of respiration heard on auscultation over the peripheral lung areas where air flows through smaller bronchioles and alveoli. It is not indicative of blockage in the trachea or larynx. D. Crackles (formerly known as rales) are discrete, discontinuous, interrupted crackling sounds that can be high-pitched or low-pitched. They are generally caused by the “popping open” of small airways and alveoli collapsed by fluid, exudate, or lack of aeration during expiration. Conditions such as pneumonia, heart failure, and pulmonary fibrosis can result in crackles. 7. Correct answer: A. Between 35 to 45 mmHg. In the human body, the normal range for partial pressure of carbon dioxide (pCO2) in arterial blood is typically between 35 to 45 millimeters of mercury (mmHg). This range represents a standard reference for evaluating the efficiency of carbon dioxide removal from the body, an essential aspect of respiratory function. Incorrect answer options: B, D. The ranges between 30 to 40 mmHg and 20 to 40 mmHg are too broad and could potentially include values that fall outside the standard normal range for pCO2. C. The range between 25 to 30 mmHg is too narrow and falls below the standard normal range for pCO2, which could indicate a state of respiratory alkalosis if found in a patient. 8. Correct answer: B. Pons and Medulla oblongata. The control center for our breathing patterns is primarily located within two areas of the brainstem: the pons and the medulla oblongata. The medulla oblongata contains the dorsal and ventral respiratory groups that mainly control the rhythm of respiration, while the pons contains the pneumotaxic and apneustic centers that regulate the rate and depth of respiration. Incorrect answer options: A. The medulla oblongata is involved in breathing regulation, but the hypothalamus is not primarily involved in direct control of respiration. The hypothalamus mainly regulates homeostatic functions such as body temperature, thirst, hunger, and sleep. C. The pons is involved in the control of breathing, but the midbrain does not play a primary role in this function. The midbrain is involved in many functions, including eye movement, auditory and visual processing, and motor control. D. The pons is involved in the control of breathing, but the hypothalamus is not primarily involved in this process. 9. Correct answer: A. Adenocarcinoma. Adenocarcinoma is the most commonly diagnosed type of lung cancer, especially in non-smokers. It originates from the cells that line the alveoli and bronchial tubes’ smaller branches and produce substances such as mucus. The growth of adenocarcinoma is usually slower compared to other types of lung cancer, providing a somewhat better prognosis. Incorrect answer options: B. Large cell carcinoma. This form of lung cancer is less common. Large cell carcinoma can appear in any part of the lung and tends to grow and spread quickly, which can make it harder to treat. C. Pleural mesothelioma. This is a rare form of lung cancer that is often associated with exposure to asbestos. It starts in the pleura, the thin layer of tissue covering the lungs and the chest wall’s inner surface. D. Oat cell carcinoma (also known as small cell lung cancer). This type of lung cancer represents about 10-15% of all cases. It grows and spreads more quickly than non-small cell lung cancer, so it’s often in advanced stages by the time it’s diagnosed. It is closely linked to smoking and has a poor prognosis compared to other lung cancers. 10. Correct answer: D. Metabolic acidosis. The provided parameters—reduced pH levels, diminished bicarbonate concentration, and low base excess—suggest metabolic acidosis. This condition occurs when the body produces too much acid or when the kidneys do not remove enough acid from the body. In response, the body utilizes bicarbonate (HCO3-) to neutralize the excess acid, hence its reduced level. The low base excess also implies an acid-base disturbance where there is a deficit of base in the body. Incorrect answer options: A. Respiratory acidosis. This condition usually results from a decrease in the removal of CO2 due to impaired respiration, causing an increase in pCO2, not a normal level. B. Respiratory alkalosis. This would be characterized by a decreased pCO2 level (due to hyperventilation), and would lead to an increase in pH, the opposite of what is seen here. C. Metabolic alkalosis. This would be associated with an increased pH level and an elevated bicarbonate level, as the body attempts to compensate for an overabundance of base or a loss of acid. 11. Correct answer: B. Bronchial hypotension. This term does not typically exist in the context of pulmonary diseases or COPD. Hypotension refers to low blood pressure and is not directly related to COPD or bronchial conditions. Incorrect answer options: A. Bronchitis. Chronic bronchitis is a common component of COPD. It is an inflammation of the lining of the bronchial tubes, which carry air to and from the air sacs (alveoli) of the lungs. C. Emphysema. This is a lung condition that causes shortness of breath due to damage to the alveoli. Over time, the inner walls of the alveoli weaken and rupture, creating larger air spaces instead of many small ones, reducing the surface area for gas exchange. Emphysema is commonly associated with COPD. D. Bronchial asthma. While it’s a different condition from COPD, both asthma and COPD can coexist in a condition called Asthma-COPD Overlap Syndrome (ACOS). Both conditions are chronic and involve airflow obstruction and inflammation in the bronchi. 12. Correct answer: B. Wheezes. Wheezing refers to a high-pitched whistling sound made while breathing, typically on exhalation (breathing out). It’s caused by narrowed airways or inflammation. Bronchial spasms, also called bronchospasms, are sudden constrictions of the muscles in the walls of the bronchioles. This results in narrowing of the airways, which can cause wheezing. Bronchospasm is a key feature in diseases such as asthma and chronic obstructive pulmonary disease (COPD). Incorrect answer options: A. Stridor. This is a high-pitched, wheezing sound caused by disrupted airflow. Stridor usually occurs due to blockage or narrowing at the larynx or trachea level, not due to bronchial spasms. C. Crackles. These are short, explosive sounds that can be heard when a person breathes in (inhales). They are usually caused by fluid accumulation in the lungs (pulmonary edema), pneumonia, or lung fibrosis, not bronchial spasms. D. Pleural Rub. This is a noise heard through a stethoscope, resembling the sound of creaking leather. This sound occurs when the two layers of the pleura in the lungs rub together, usually due to inflammation or disease, and is not related to bronchial spasms. 13. Correct answer: C. Guaifenesin. Guaifenesin is an expectorant that is commonly used to relieve chest congestion. It works by thinning the mucus in the air passages, making it easier to cough up and clear the airways. This helps to enhance respiratory tract fluidity and facilitate mucus clearance. Incorrect answer options: A. Benadryl. Benadryl is a brand name for diphenhydramine, an antihistamine used to relieve symptoms of allergies, hay fever, and the common cold. It is not an expectorant. B. Theophylline. This is a bronchodilator used for treating asthma and other lung diseases such as emphysema and chronic bronchitis. While it can help to open up the airways, it is not an expectorant. D. Acetylcysteine. This is a mucolytic agent that helps to thin and loosen mucus in the airways, but it is not classified as an expectorant. It’s typically used in patients with conditions like cystic fibrosis where thick, sticky mucus is a significant problem. 14. Correct answer: C. Theophylline. Theophylline is a bronchodilator medication. It belongs to a class of drugs called xanthines, and it works by relaxing the smooth muscle around the airways in your lungs. This allows the bronchi and bronchioles to expand, leading to increased airflow and easier breathing. Theophylline also has some anti-inflammatory effects which may further aid in reducing bronchoconstriction. Theophylline is used in the treatment of respiratory diseases like asthma and chronic obstructive pulmonary disease (COPD). Incorrect answer options: A. Acetaminophen. This is a pain reliever (analgesic) and fever reducer (antipyretic). It does not have bronchodilator effects, and hence, it does not work to expand the airways in the lungs. B. Acetylcysteine. Acetylcysteine is a mucolytic medication. It breaks down the thick mucus in the airways, aiding its expulsion. However, it does not have bronchodilator properties to directly widen the airways. D. Guaifenesin. Guaifenesin is an expectorant. It works by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. This aids in the clearance of mucus from the airways. Although it assists in maintaining open airways, it doesn’t work by directly dilating or expanding the airways like bronchodilators do. 15. Correct answer: C. Pentamidine. Pentamidine is an antimicrobial agent that is specifically used for treating Pneumocystis carinii pneumonia (also known as Pneumocystis jirovecii pneumonia), a type of fungal infection. It is typically used in patients who are immunocompromised, such as those with HIV/AIDS, as they are at a higher risk of developing this type of infection. Incorrect answer options: A. Lorazepam. Lorazepam is a benzodiazepine, primarily used to treat anxiety disorders. It can also be used for insomnia, epilepsy, and sedation for various procedures. It does not have any antimicrobial properties and is not used to treat infections. B. Epinephrine HCL. Epinephrine, also known as adrenaline, is used to treat severe allergic reactions (anaphylaxis) due to its ability to constrict blood vessels, dilate bronchioles, and stimulate the heart. It is not used to combat infections. D. Chlorpropamide. Chlorpropamide is a sulfonylurea antidiabetic medication used to control blood sugar levels in patients with type 2 diabetes. It has no activity against fungal infections. 16. Correct answer: C. Theophylline. Theophylline is a drug that belongs to a class of compounds known as xanthines. Xanthines act as bronchodilators, meaning they relax and widen the bronchi and bronchioles in the lungs, facilitating airflow and making it easier for patients to breathe. This class of drugs, which also includes caffeine and theobromine, has been used to treat respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Incorrect answer options: A. Epinephrine Hydrochloride. Epinephrine, also known as adrenaline, is a catecholamine that acts as a potent vasoconstrictor and bronchodilator. It is used for emergencies including anaphylactic reactions and cardiac arrest but is not a xanthine derivative. B. Glimepiride. Glimepiride is a sulfonylurea, a class of oral medications used to treat type 2 diabetes by stimulating the pancreas to produce more insulin. It does not belong to the xanthine class. D. Guaifenesin. Guaifenesin is an expectorant. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. It does not have the bronchodilating properties of xanthine medications. 17. Correct answer: B. Headaches. While headaches can be a symptom experienced by some patients with Chronic Obstructive Pulmonary Disease (COPD), especially those with severe disease or during exacerbations due to hypoxia or hypercapnia, they are not typically a direct result of the disease. Most COPD-related complications affect the respiratory system or other parts of the body due to low oxygen levels. In contrast, headaches can be caused by a wide variety of conditions, not just COPD. Incorrect answer options: A. Right-sided heart failure. This can occur as a result of COPD. Chronic low oxygen levels and high carbon dioxide levels caused by COPD can put a strain on the heart, particularly the right side, which pumps blood to the lungs. Over time, this can lead to right-sided heart failure, also known as cor pulmonale. C. Pneumonia. People with COPD are at an increased risk of developing pneumonia because the disease damages the lungs, making them more susceptible to infections. This is also the reason why people with COPD are usually advised to get regular vaccinations against pneumococcal bacteria and influenza. D. Cor pulmonale. This is a condition characterized by enlargement and potential failure of the right side of the heart as a response to increased vascular resistance or high blood pressure in the lungs. In the context of COPD, this happens due to prolonged hypoxia leading to pulmonary hypertension, causing an increased workload on the right side of the heart. 18. Correct answer: A. Acetylcysteine. Acetylcysteine is a mucolytic drug. It works by breaking down the chemical structure of mucus, making it less thick and sticky and easier to cough up. This helps clear the airways in conditions where mucus is a problem, such as in chronic obstructive pulmonary disease (COPD) or cystic fibrosis. Incorrect answer options: B. Theophylline. Theophylline is a bronchodilator and it belongs to the xanthine class of drugs. It relaxes and widens the bronchi and bronchioles in the lungs, improving airflow. However, it does not work to thin mucus like a mucolytic would. C. Guaifenesin. Guaifenesin is an expectorant. It works by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. This aids in the clearance of mucus from the airways. While it helps in maintaining open airways, it doesn’t work by directly breaking down mucus like a mucolytic. D. Atorvastatin. Atorvastatin is a statin medication used to lower cholesterol levels in the blood. It has no role in breaking down mucus or in managing respiratory conditions. 19. Correct answer: D. Vital Capacity. Vital Capacity (VC) is the maximum amount of air a person can expel from the lungs after a maximum inhalation. It is equal to the sum of the Inspiratory Reserve Volume (IRV), the Expiratory Reserve Volume (ERV), and the Tidal Volume (TV). Essentially, it represents the total volume of air that can be moved in and out of the lungs and it is useful in assessing the strength of thoracic muscles and the function of the lungs. Incorrect answer options: A. Inspiratory Reserve Volume (IRV) is the maximum amount of additional air that can be inhaled after a normal, quiet inhalation. B. Inspiratory Capacity (IC) is the maximum amount of air that can be inhaled after a normal, quiet exhalation. It is the sum of the Tidal Volume (TV) and the Inspiratory Reserve Volume (IRV). C. Expiratory Reserve Volume (ERV) is the additional amount of air that can be expired from the lungs by determined effort after normal expiration. 20. Correct answer: A. Inspiratory Reserve Volume. The Inspiratory Reserve Volume (IRV) is defined as the amount of air that can be forcefully inhaled after a normal, quiet inhalation. This measurement is used to help evaluate lung function and capacity. Incorrect answer options: B. Inspiratory Capacity. The Inspiratory Capacity (IC) is the total amount of air that can be inhaled after a normal exhalation. It includes both the Tidal Volume (TV), which is the volume of a normal breath, and the Inspiratory Reserve Volume (IRV). C. Vital Capacity. The Vital Capacity (VC) is the maximum amount of air a person can expel from the lungs after a maximum inhalation. It is the total of Inspiratory Reserve Volume (IRV), Expiratory Reserve Volume (ERV), and Tidal Volume (TV). D. Expiratory Reserve Volume. The Expiratory Reserve Volume (ERV) is the maximum amount of air that can be forcefully exhaled after a normal, quiet exhalation.Practice Mode
Exam Mode
Text Mode
Questions
B. Metabolic acidosis
C. Respiratory acidosis
D. Metabolic alkalosis
B. From 22 to 26 mEq/L.
C. From 24 to 29 mEq/L.
D. From 20 to 35 mEq/L.
B. Induration measuring between 0 to 6 millimeters after 48 hours.
C. Induration measuring between 0 to 5 millimeters after 48 hours.
D. Induration measuring between 0 to 7 millimeters after 48 hours.
– Increased bicarbonate (HCO3) concentration
– High base excess (BE)
– Normal levels of partial pressure of carbon dioxide (pCO2)
B. Respiratory alkalosis
C. Metabolic alkalosis
D. Respiratory acidosis
B. Alveolar cell of the second type.
C. Alveolar cell of the third type.
D. Alveolar cell of the first type.
B. Vesicular
C. Stridor
D. Crackles
B. Between 30 to 40 mmHg.
C. Between 25 to 30 mmHg.
D. Between 20 to 40 mmHg.
B. Pons and Medulla oblongata.
C. Midbrain and Pons.
D. Pons and Hypothalamus.
B. Large cell carcinoma
C. Pleural mesothelioma
D. Oat cell carcinoma (also known as small cell lung cancer)
– Diminished bicarbonate (HCO3) concentration
– Low base excess (BE)
– Normal levels of partial pressure of carbon dioxide (pCO2)
B. Respiratory alkalosis
C. Metabolic alkalosis
D. Metabolic acidosis
B. Bronchial hypotension
C. Emphysema
D. Bronchial asthma
B. Wheezes
C. Crackles
D. Pleural Rub
B. Theophylline
C. Guaifenesin
D. Acetylcysteine
B. Acetylcysteine
C. Theophylline
D. Guaifenesin
B. Epinephrine HCL
C. Pentamidine
D. Chlorpropamide
B. Glimepiride
C. Theophylline
D. Guaifenesin
B. Headaches
C. Pneumonia
D. Cor pulmonale
B. Theophylline
C. Guaifenesin
D. Atorvastatin
B. Inspiratory Capacity
C. Expiratory Reserve Volume
D. Vital Capacity
B. Inspiratory Capacity
C. Vital Capacity
D. Expiratory Reserve VolumeAnswers and Rationales