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EXPLANATION
✔Correct answer:
Vitamin B3. Pellagra is a disease caused by a deficiency of niacin (Vitamin B3) and is characterized by the "three Ds": dermatitis, diarrhea, and dementia. If left untreated, it can also lead to a fourth D, death. Niacin is essential for the metabolism of carbohydrates, fats, and proteins, and it plays a critical role in cellular metabolism and DNA repair.
Niacin is a water-soluble vitamin that is converted into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), coenzymes essential for energy production and cellular functions. A deficiency in niacin disrupts these metabolic processes, leading to the symptoms of pellagra. The skin, gastrointestinal system, and nervous system are particularly affected due to their high turnover rates and energy demands.
Think of niacin like the fuel needed to keep a machine running smoothly. Without enough fuel, the machine (body) starts to malfunction, showing signs of wear (dermatitis), inefficient operation (diarrhea), and system errors (dementia).
Managing pellagra involves supplementing niacin and addressing dietary deficiencies:
- Administering niacin supplements to correct the deficiency.
- Encouraging a balanced diet rich in niacin, including foods like meat, fish, eggs, green vegetables, and grains.
- Monitoring and managing symptoms such as skin lesions and gastrointestinal disturbances.
- Educating the patient on the importance of maintaining a diet sufficient in essential vitamins to prevent recurrence.
✘Incorrect answer options:
Vitamin B1. Deficiency of Vitamin B1 (thiamine) leads to beriberi, which affects the cardiovascular and nervous systems, not pellagra. Symptoms of thiamine deficiency include weight loss, emotional disturbances, impaired sensory perception, weakness, and pain in the limbs.
Vitamin B2. Deficiency of Vitamin B2 (riboflavin) causes ariboflavinosis, which can lead to sore throat, redness and swelling of the lining of the mouth and throat, cracks or sores on the outsides of the lips (cheilosis) and at the corners of the mouth (angular stomatitis), and a moist, scaly skin inflammation (seborrheic dermatitis).
Vitamin B6. Deficiency of Vitamin B6 (pyridoxine) can lead to microcytic anemia, depression, confusion, and weakened immune function. While important, it does not cause pellagra.
References
- McCance, K. L., Huether, S. E., Brashers, V. L., & Rote, N. S. (2018). Pathophysiology: The Biologic Basis for Disease in Adults and Children. Elsevier.
- Hockenberry, M. J., & Wilson, D. (2018). Wong's Nursing Care of Infants and Children. Elsevier.