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EXPLANATION
✔Correct answer:
Plaque formations obstruct the arterial passage. Atherosclerosis, the underlying cause of coronary artery disease (CAD), is characterized by the buildup of plaques on the inner walls of the arteries. These plaques, consisting of fats, cholesterol, calcium, and other substances found in the blood, progressively narrow and block the arteries, reducing blood flow to the heart muscle. This process doesn't just reduce the lumen (interior space) of the arteries but can also make them less flexible, a condition known as arteriosclerosis. When the coronary arteries are affected, the heart muscle may not receive the oxygen-rich blood it needs, leading to chest pain (angina), shortness of breath, or other coronary artery disease signs and symptoms. In severe cases, plaque rupture and subsequent blood clot formation can lead to heart attack.
Imagine a garden hose as an artery. When the hose is new and clean, water flows freely through it. However, if mud (akin to plaques) starts to accumulate inside the hose, the pathway for water becomes narrower, and the flow of water (blood) is reduced. If enough mud accumulates, it might eventually block the hose completely, stopping the flow entirely.
In a healthy state, the coronary arteries supply the heart muscle (myocardium) with blood rich in oxygen and nutrients. The endothelium (inner lining) of these arteries is smooth and unobstructed, allowing for easy blood flow. However, in atherosclerosis, the endothelium becomes damaged, and plaques begin to form, leading to a narrowed lumen and reduced blood flow. This can cause ischemia (reduced blood flow) and lead to symptoms like chest pain. If a plaque ruptures, it can form a clot that completely obstructs the artery, leading to myocardial infarction (heart attack).
✘Incorrect answer options:
Blood coagulates outside the vessel wall. This statement is incorrect. Blood coagulation, or clotting, typically occurs within the vessels, often as a response to vessel injury or plaque rupture, not outside them.
Plaque formations obstruct the venous passage. This statement is incorrect in the context of coronary artery disease. While veins can be affected by conditions like deep vein thrombosis, CAD specifically involves the arteries, especially the coronary arteries supplying the heart.
Hardened vessels expand to facilitate blood flow. This statement is incorrect. Hardening of the vessels, known as arteriosclerosis, actually makes them less flexible and more narrow, not expanded. This reduces the blood flow, contrary to what the statement suggests.
References
- Porth, C. M., & Matfin, G. (2009). Pathophysiology: Concepts of Altered Health States. Lippincott Williams & Wilkins.
- Ignatavicius, D. D., Workman, M. L., & Rebar, C. R. (2015). Medical-Surgical Nursing: Patient-Centered Collaborative Care. Elsevier Health Sciences.