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EXPLANATION
✔Correct answer:
Immature neutrophils (bands) outnumbering mature neutrophils (segmented neutrophils or "segs"). A finding of immature neutrophils (bands) outnumbering mature neutrophils (segmented neutrophils, or "segs") is referred to as a "left shift" in the white blood cell differential. This phenomenon occurs when the body responds to a severe infection or inflammation, such as in sepsis. The bone marrow releases an increased number of immature neutrophils (bands) into the bloodstream to compensate for the heightened demand for immune response.
In a burn patient, a left shift is particularly concerning because burns compromise the immune system and serve as a fertile ground for infections due to the loss of the skin barrier, necrotic tissue, and invasive medical interventions. When coupled with other clinical signs (e.g., fever, tachycardia, hypotension), a left shift strongly suggests the potential for sepsis.
During a severe infection or systemic inflammatory response, neutrophils are rapidly consumed at the site of infection. The bone marrow accelerates neutrophil production and releases immature forms (bands) before they fully mature. Normally, segmented neutrophils are the predominant type of neutrophil in circulation, and bands make up only 3-5% of the total. When bands outnumber segs, it signals that the body is under significant stress, potentially indicative of sepsis.
Think of the immune system like an army. The "experienced soldiers" (mature neutrophils) are usually deployed first to fight infection. In cases of severe infection (like sepsis), the "rookies" (immature neutrophils) are sent to the battlefield because the experienced soldiers are depleted. A higher number of rookies than veterans signals an urgent and overwhelming situation.
Recognizing a left shift is critical for initiating timely interventions to prevent the progression of sepsis.
- Assess for clinical signs of sepsis, such as fever, altered mental status, tachycardia, hypotension, and decreased urine output.
- Ensure blood cultures and other relevant cultures are obtained to identify the source of infection.
- Anticipate and administer broad-spectrum antibiotics as prescribed, followed by pathogen-specific therapy once cultures are available.
- Monitor trends in laboratory values, including lactate levels, procalcitonin, and white blood cell counts.
- Support organ perfusion through fluid resuscitation, vasopressors, and oxygen therapy as necessary.
✘Incorrect answer options:
A total white blood cell count of 9,000/mm3. A total WBC count of 9,000/mm3 is within the normal range (4,500–11,000/mm3) and does not suggest sepsis. It is the differential and the presence of immature neutrophils (bands) that are more specific indicators of infection severity.
Lymphocytes being more numerous than basophils. This finding is not clinically significant in the context of sepsis. Lymphocytes are typically more numerous than basophils under normal circumstances and do not provide specific information about the presence of sepsis.
A monocyte count of 1,800/mm3. While monocytes can increase during chronic infections and inflammatory states, they are not the primary cells involved in the acute response to bacterial infections. An isolated rise in monocytes is not specific for sepsis and is less clinically relevant compared to the presence of a left shift in neutrophils.
References
- Ignatavicius, D. D., Workman, M. L., Rebar, C. R., & Heimgartner, N. M. (2018). Medical-Surgical Nursing: Concepts for Interprofessional Collaborative Care. Elsevier.
- Lewis, S. L., Bucher, L., Heitkemper, M. M., & Harding, M. M. (2017). Medical-Surgical Nursing: Assessment and Management of Clinical Problems. Elsevier.