Antiparkinsonism Drugs Nursing Considerations & Management

Antiparkinsonism agents are drugs used for management of signs and symptoms of Parkinson’s disease, a progressive, chronic neurological disorder primarily characterized by lack of coordination. Over time, individuals with Parkinson’s develop rigidity and weakness.

There is no known treatment for Parkinson’s as of present and drug therapy remains to be the primary treatment.

The goal of the therapy is to restore the balance between decreasing dopamine levels (has inhibitory effect on the neurons of the basal ganglia) and increasing cholinergic neurons (excitatory).

Table of Common Drugs and Generic Names

Here is a table of commonly encountered antiparkinsonism agents, their generic names, and brand names:

Disease Spotlight: Parkinson’s Disease and Parkinsonism

Parkinson’s Disease

• Parkinson’s Disease is a chronic, progressive neurological disorder with rhythmic tremors as its initial manifestation. These tremors lead to rigidity and weakness which interfere with the ability to maintain posture.
• Other manifestations include bradykinesia (extremely slowed movements), shuffling gait, drooling, and slow and slurred speech. Cranial nerve affectations lead to a mask-like expression.
• It is important to note that Parkinson’s does not affect the higher levels of cerebral cortex so intelligence and other brain functions at the same level are intact.
• The actual cause of Parkinson’s is not known but the manifestations are directly related to the damaged neurons in the basal ganglia of the brain. Neuronal damage is thought to be caused by viral infections, head trauma, brain infections, atherosclerosis, and drug and environmental exposures.

Parkinsonism

• Parkinsonism is referred to as the Parkinson’s disease-like extrapyramidal symptoms which are associated to particular drugs or brain injuries’ adverse effects.

Dopaminergic Agents

Description

• Drugs that increase the effects of dopamine at receptor sites.

Therapeutic Action

The desired and beneficial actions of dopaminergics are as follows:

• Dopamine does not cross the blood-brain barrier so other drugs with actions similar to dopamine and those that increase its concentration in the substantia nigra (area responsible for muscle tone) must be used. This is one way of restoring the balance between stimulatory and inhibitory neurotransmitters.
• Levodopa, the precursor of dopamine is the mainstay of treatment for Parkinson’s. It crosses the blood-brain barrier and is converted into dopamine. When combined with carbidopa, the enzyme dopa decarboxylase is inhibited from metabolizing levodopa, leading to higher levels that can cross the barrier.

Indications

Dopaminergics are indicated for the following medical conditions:

• Dopaminergics are indicated for the relief of the signs and symptopms of idiopathic Parkinson’s disease.
• Levodopa is the drug of choice and acts as a replacement therapy.
• Amantadine is an antiviral drug that increases release of dopamine.
• Apomorphine directly binds with postsynaptic dopamine receptors. 

Here are some important aspects to remember for indication of dopaminergics in different age groups:

Children

Safety and effectiveness of dopaminergics in children has not been established. Parkinson’s in children is very rare but they do experience parkinsonian symptoms because of other drugs. In this case, diphenhydramine is the drug of choice.

Adults

They must receive education about how to cope with the disease and the effects of the drugs. Herbal and alternative therapies should be mentioned to health care team because of drug interactions that may minimize effectiveness of therapy. Vitamin B₆ can cause serious problems when taken with dopaminergics. Women of childbearing age should use contraception because of potential adverse effects to fetus. Lactating women should also use other method of feeding because of potential adverse effects to the baby.

Older adults

They are more susceptible to drug effects so dose for older adults need to be frequently adjusted. It can worsen other existing medical conditions like glaucoma and benign prostatic hypertrophy. An extensive written drug-teaching protocol is essential.

Pharmacokinetics

Here are the characteristic interactions of dopaminergics and the body in terms of absorption, distribution, metabolism, and excretion:

Contraindications and Cautions

The following are contraindications and cautions for the use of dopaminergics:

• Allergy to dopaminergics. Prevent hypersensitivity reactions
• Angle-closure glaucoma. Can be exacerbated by drug effects
• Lactation. Can enter breast milk and cause adverse effects to the baby
• Pregnancy. Can enter
• Suspicious skin lesions. Levodopa is associated with development of melanoma
• CV disease, bronchial asthma, psychiatric disorders. Can be exacerbated by dopamine receptor stimulation
• Hepatorenal diseases. Can interfere with metabolism and excretion of drug
• Apomorphine can increase risk of hypotension and prolonged QT interval.

Adverse Effects

Use of dopaminergics may result to these adverse effects:

• CNS: anxiety, nervousness, headache, malaise, fatigue, confusion, mental changes, blurred vision, muscle twitching, and ataxia
• CV: arrhythmias, hypotension, palpitation
• Respiratory: bizarre breathing patterns
• GI: anorexia, nausea, vomiting, dysphagia, constipation or diarrhea
• GU: urinary retention
• Others: flushing, increased sweating, hot flashes

Interactions

The following are drug-drug interactions involved in the use of dopaminergics:

• MAOI: Increased therapeutic effects and risk of hypertensive crisis. MAOI should be stopped 14 days before beginning dopaminergic therapy.
• Vitamin B_6, phenytoin: decreased levodopa efficacy
• Over-the-counter vitamins: decreased dopaminergic effectiveness

Nursing Considerations

Here are important nursing considerations when administering this drug:

Nursing Assessment

These are the important things the nurse should include in conducting assessment, history taking, and examination:

• Assess for mentioned contraindications and cautions (e.g. drug allergy, GI depression or obstruction, BPH, glaucoma) to prevent untoward complications.
• Perform a thorough physical assessment (e.g. CNS, respiratory status, vital signs, CV status, bowel sounds, urine output ) to obtain baseline data, determine drug therapy effectiveness, and monitor adverse effects.
• Assess skin for suspicious lesions if levodopa is to be given because it can cause or exacerbate melanoma.
• Assess for history of prolonged QT interval and obtain electrocardiogram if apomorphine is to be given to prevent further prolonged QT interval and serious arrhythmias.
• Monitor laboratory test results (liver and renal function, CBC) to determine need for possible dose adjustment and for evaluation of possible bone marrow suppression.

Nursing Diagnoses

Here are some of the nursing diagnoses that can be formulated in the use of this drug for therapy:

• Disturbed thought processes related to CNS effects
• Constipation related to dopaminergic effects
• Risk for urinary retention related to dopaminergic effects
• Risk for injury related to CNS effects and orthostatic hypotension

Implementation with Rationale

These are vital nursing interventions done in patients who are taking dopaminergics:

• Decrease dose of drug as ordered if therapy has been interrupted to prevent systemic dopaminergic effects.
• Evaluate disease progress and signs and symptoms periodically for reference of disease progress and drug response.
• Give drug with meals to alleviate GI irritation if present.
• Monitor bowel function and institute bowel program if constipation is severe.
• Have patient void before taking the drugs to decrease risk of urinary retention.
• Monitor laboratory test results (renal and liver function, CBC) to detect early signs of dysfunction.
• Provide comfort measures to help patient tolerate drug effects.
• Provide safety measures (e.g. adequate lighting, raised side rails, etc.) to prevent injuries.
• Educate client on drug therapy to promote understanding and compliance.

Evaluation

Here are aspects of care that should be evaluated to determine effectiveness of drug therapy:

• Monitor patient response to therapy (improvement in signs and symptoms of Parkinson’s disease).
• Monitor for adverse effects (e.g.CNS changes, urinary retention, GI depression, increased sweating and flushing, etc).
• Evaluate patient understanding on drug therapy by asking patient to name the drug, its indication, and adverse effects to watch for.
• Monitor patient compliance to drug therapy.

Anticholinergic Agents

Description

• Anticholinergic agents are synthetic drugs which have been developed to achieve a greater affinity for cholinergic receptor sites in the CNS.
• Drugs that inhibit the effects of acetylcholine at receptor sites of substantia nigra and corpus striatum.

Therapeutic Action

The desired and beneficial actions of anticholinergic agents are as follows:

• Returns the balance to the basal ganglia and reduces the severity of rigidity, akinesia, and tremors.
• Peripheral anticholinergics reduce drooling and other secondary effects of parkinsonism.

Indications

Anticholinergic agents are indicated for the following medical conditions:

• Adjunctive therapy for Parkinson’s disease (idiopathic, atherosclerotic, and postencephalitic)
• Indicated for patients who no longer respond to levodopa.

Here are some important aspects to remember for indication of anticholinergic agents in different age groups: 

Children

Safety and effectiveness of dopaminergics in children has not been established. Parkinson’s in children is very rare but they do experience parkinsonian symptoms because of other drugs. In this case, diphenhydramine is the drug of choice.

Adults

They must receive education about how to cope with the disease and the effects of the drugs. Herbal and alternative therapies should be mentioned to health care team because of drug interactions that may minimize effectiveness of therapy. Vitamin B₆ can cause serious problems when taken with anticholinergics. Women of childbearing age should use contraception because of potential adverse effects to fetus. Lactating women should also use other method of feeding because of potential adverse effects to the baby.

Older adults

They are more susceptible to drug effects so dose for older adults need to be frequently adjusted. It can worsen other existing medical conditions like glaucoma and benign prostatic hypertrophy. An extensive written drug-teaching protocol is essential.

Pharmacokinetics

Here are the characteristic interactions of anticholinergic agents and the body in terms of absorption, distribution, metabolism, and excretion:

Contraindications and Cautions

The following are contraindications and cautions for the use of anticholinergic agents:

• Allergy to dopaminergics. Prevent hypersensitivity reactions
• Angle-closure glaucoma, GI and GU obstruction, prostatic hypertrophy. Can be exacerbated by drug effects
• Myasthenia gravis. Exacerbated by acetylcholine receptor sites blocking effect of the drug
• Tachycardia, dysrhythmia, hyper or hypotension. Blocking the parasympathetic system may cause a dominance of sympathetic stimulatory activity
• Hepatic dysfunction. Interfere with the metabolism of drugs increasing risk of toxicity
• Lactation. Can enter breast milk and cause adverse effects to the baby
• Pregnancy. Can enter

Adverse Effects

Use of anticholinergic agents may result to these adverse effects:

• CNS: disorientation, confusion, memory loss, agitation, nervousness, delirium, dizziness, light-headedness, weakness
• CV: tachycardia, palpitations, hypotension
• EENT: blurred vision, photophobia, pupil dilation, blocking of lens accommodation
• GI: dry mouth, nausea, vomiting, paralytic ileus, constipation
• GU: urinary retention and hesitancy
• Others: flushing, reduced sweating

Interactions

The following are drug-drug interactions involved in the use of anticholinergic agents:

• TCAs, phenothiazines: increased risk of potentially fatal paralytic ileus and toxic psychoses
• Antipsychotics: decreased antipsychotic therapeutic effectiveness because of central antagonism of two agents

Nursing Considerations

Here are important nursing considerations when administering this drug:

Nursing Assessment

These are the important things the nurse should include in conducting assessment, history taking, and examination:

• Assess for mentioned contraindications and cautions (e.g. drug allergy, GI depression or obstruction, glaucoma, myasthenia gravis) to prevent untoward complications.
• Perform a thorough physical assessment (e.g. CNS, respiratory status, vital signs, CV status, bowel sounds, urine output) to obtain baseline data, determine drug therapy effectiveness, and monitor adverse effects.
• Monitor laboratory test results (liver and renal function) to determine need for possible dose adjustment.

Nursing Diagnoses

Here are some of the nursing diagnoses that can be formulated in the use of this drug for therapy:

• Disturbed thought processes related to CNS effects
• Impaired urinary elimination related to genitourinary effects
• Constipation related to GI effects
• Risk for impaired thermoregulation related to anticholinergic effects
• Risk for injury related to CNS effects

Implementation with Rationale

These are vital nursing interventions done in patients who are taking anticholinergics:

• Administer drug with caution for patients exposed in hot weather or environments because patients are at increased risk for heat prostration due to decreased ability to sweat.
• Give drug with meals to alleviate GI irritation if present.
• Monitor bowel function and institute bowel program if constipation is severe.
• Have patient void before taking the drugs to decrease risk of urinary retention.
• Monitor laboratory test results (renal and liver function) to detect early signs of dysfunction.
• Provide comfort measures to help patient tolerate drug effects.
• Provide safety measures (e.g. adequate lighting, raised side rails, etc.) to prevent injuries.
• Educate client on drug therapy to promote understanding and compliance.
• Evaluate disease progress and signs and symptoms periodically for reference of disease progress and drug response.

Evaluation

Here are aspects of care that should be evaluated to determine effectiveness of drug therapy:

• Monitor patient response to therapy (improvement in signs and symptoms of Parkinson’s disease).
• Monitor for adverse effects (e.g.CNS changes, urinary retention, GI depression, decreased sweating, etc).
• Evaluate patient understanding on drug therapy by asking patient to name the drug, its indication, and adverse effects to watch for.
• Monitor patient compliance to drug therapy.

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